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BSJ-04-132 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity.
| Molecular Weight | 819.91 |
| Formula | C42H49N11O7 |
| CAS Number | 2349356-39-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage | -20°C, dry, sealed |
| Related PROTAC Products |
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| xStAx-VHLL TFA
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| MTX-23
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| YD23
YD23 is a SMARCA2 PROTAC. |
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