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Bropirimine is a synthetic agonist of Toll-like receptor 7 (TLR7). Bropirimine inhibits osteoclast differentiation from osteoclast precursor cells through TLR7-mediated IFN-β production. Bropirimine is an oral active immunomodulator with anticancer activity in transitional cell carcinoma in situ (CIS) of the bladder and upper urinary tract.
| Molecular Weight | 266.09 |
| Formula | C10H8BrN3O |
| CAS Number | 56741-95-8 |
| Solubility (25°C) | DMSO: ≥5 mg/mL (warm DMSO) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] M A Wynalda, et al. Characterization of bropirimine O-glucuronidation in human liver microsomes
[4] J A Witjes. Treatment of carcinoma in situ of the urinary bladder with bropirimine
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