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BPR1K871

Cat. No. M29644

All AbMole products are for research use only, cannot be used for human consumption.

BPR1K871 Structure
Synonym:

DBPR114

Price and Availability

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Quality Control & Documentation
Biological Activity

BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development candidate for anti-cancer therapy.

Chemical Information
Molecular Weight 526.05
Formula C25H28ClN7O2S
CAS Number 2443767-35-7
Form Solid
Solubility (25°C) DMSO 125 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kun-Hung Lee, et al. J Med Chem. Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model

[2] Mu-Chun Li, et al. Eur J Med Chem. Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization

[3] Shu-Yu Lin, et al. Bioorg Chem. Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors

[4] Yung Chang Hsu, et al. Oncotarget. Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation

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  Catalog
Abmole Inhibitor Catalog




Keywords: BPR1K871, DBPR114 supplier, FLT3, inhibitors, activators

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