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Bococizumab

Cat. No. M24650
Bococizumab Structure
Synonym:

PF-04950615; RN316

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Quality Control & Documentation
Biological Activity

Bococizumab (PF-04950615) is an anti-human PCSK9 inhibitory antibody that reduces LDL cholesterol levels. Bococizumab can be used in the research of hypercholesterolemia.

Chemical Information
CAS Number 1407495-02-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Daniel Steffens, et al. Expert Opin Biol Ther. PCSK9 inhibitors and cardiovascular outcomes

[2] Massimiliano Ruscica, et al. Atherosclerosis. PCSK9 inhibition and inflammation: A narrative review

[3] Nicola Ferri, et al. Expert Opin Biol Ther. Bococizumab for the treatment of hypercholesterolaemia

[4] Paul M Ridker, et al. N Engl J Med. Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

[5] Nicola Ferri, et al. Expert Opin Biol Ther. Bococizumab for the treatment of hypercholesterolaemia

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  Catalog
Abmole Inhibitor Catalog




Keywords: Bococizumab, PF-04950615; RN316 supplier, PCSK9, inhibitors, activators


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