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PCSK9 Proprotein convertase subtilisin/kexin type 9

Cat.No.  Name Information
M3835 Alirocumab Alirocumab is a humanized IgG1 PCSK9 monoclonal antibody that can be used in the study of hypercholesterolemia.
M11343 Pinostrobin Pinostrobin is a flavonoid found in many plants and has antioxidant, anti-inflammatory, anticancer and neuroprotective properties. Pinostrobin is an effective INHIBITOR of PCSK9, which can inhibit the catalytic activity of PCSK9. Pinostrobin is a promising agent for cholesterol regulation and lipid management.
M11162 Pep2-8 Pep2-8 is a PCSK9 inhibitor, of which KD The value is 0.7 μM,IC50 The value is 1.4 μM.
M10699 SBC-115337 SBC-115337 is a potent benzofuran compound that is an inhibitor of PCSK9,IC50 The value is 0.5 μM.
M9966 PF-06446846 hydrochloride PF-06446846 hydrochloride is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9.
M9867 SBC-110736 SBC-110736 is a novel inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9).
M7542 SBC-115076 Sbc-115076 is an effective inhibitor of the preprotein invertase Bacillus subtilis proteinase/Kexin 9 (PCSK9). PCSK9 is a preprotein invertase that plays an important role in LDL receptor metabolism.
M6251 R-IMPP R-impp (PF-00932239) is an anti-secreting inhibitor of PCSK9 (IC50=4.8 μM), which can inhibit PCSK9 protein translation by targeting the ribosomes at the time of 80S.
M4247 Schizandrol-B Schisantherin B (Gomisin-B; Wuweizi ester-B; Schisantherin-B) is a lignan from Schisandra chinensis that promotes liver enlargement in mice through activation of the PXR and YAP pathways and inhibits PCSK9 protein expression with an IC50 value of 1.10 μM.
M1595 Evolocumab Evolocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9).
M45130 NNC0385-0434 NNC0385-0434 is an orally active peptide small molecule PCSK9 inhibitor for atherosclerosis-related studies.
M45129 CiVi-008 CiVi-008 is an orally active PCSK9 antisense oligonucleotide (ASO) inhibitor for studies related to disorders of lipid metabolism.
M45128 CiVi-007 CiVi-007 is an antisense oligonucleotide (ASO) polymerized with N-acetylglucosamine that targets PCSK9 and can be used in studies related to hypercholesterolemia.
M45125 AZD-8233 AZD-8233 is an orally active, antisense oligonucleotide (ASO) targeting PCSK9 that targets and inhibits the translation and protein synthesis of PCSK9 mRNA in hepatocytes and reduces circulating LDL-C levels. It can be used in studies related to hypercholesterolemia.
M40600 Ebronucimab Ebronucimab is a monoclonal antibody to PCSK9 that can be used in studies related to hypercholesterolemia.
M28735 PF-06446846  PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 directly and selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region.
M25402 Enlicitide chloride Enlicitide (MK-0616) chloride is an oral PCSK9 macrocyclic peptide inhibitor.
M25092 Recaticimab Recaticimab (SHR-1209) is a humanized monoclonal antibody that inhibits PCSK9. Receticimab mediates the degradation of PCSK9 by binding to PCSK9, increasing the level of low-density lipoprotein (LDL) receptors on the surface of hepatocytes, reducing the level of LDL in plasma, and achieving the goal of lowering blood lipids. Recaticimab has potential application in hypercholesterolemia.
M25040 Lerodalcibep Lerodalcibep (LIB003) is a recombinant fusion protein of a PCSK9-binding domain (adnectin) and human serum albumin. Lerodalcibep is a Lipid-lowering agent. Lerodalcibep can be used for the research of hypercholesterolemia and cardiovascular diseases.
M24997 Tafolecimab Tafolecimab (IBI-306) is a human lgG2 monoclonal antibody that specifically binds PCSK-9 and reduces LDL-C levels by inhibiting PCSK-9-mediated endocytosis of the LDL receptor, which in turn enhances clearance of LDL-C and leads to a reduction in LDL-C levels. Tafolecimab may be used in studies of hypercholesterolaemia.




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