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Pep2-8

Cat. No. M11162
Pep2-8 Structure
Size Price Availability Quantity
5mg USD 280  USD280 In stock
10mg USD 460  USD460 In stock
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Biological Activity

Pep2-8 is a PCSK9 inhibitor, of which KD The value is 0.7 μM,IC50 The value is 1.4 μM.

Chemical Information
Molecular Weight 1715.88
Formula C83H110N16O24
CAS Number 1541011-97-5
Storage protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Victoria Harbour, et al. ACS Appl Bio Mater. Regulation of Lipoprotein Homeostasis by Self-Assembling Peptides

[2] Kvin Bourbiaux, et al. J Med Chem. Potent Lys Patch-Containing Stapled Peptides Targeting PCSK9

[3] Carmen Lammi, et al. Sci Rep. Biological Characterization of Computationally Designed Analogs of peptide TVFTSWEEYLDWV (Pep2-8) with Increased PCSK9 Antagonistic Activity

[4] Zufeng Ding, et al. Cardiovasc Res. PCSK9 expression in the ischaemic heart and its relationship to infarct size, cardiac function, and development of autophagy

[5] Yingnan Zhang, et al. J Biol Chem. Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor

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  Catalog
Abmole Inhibitor Catalog




Keywords: Pep2-8 supplier, PCSK9, inhibitors, activators

 
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