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Bisantrene is an antineoplastic agent, MDR1 substrate, DNA intercalator, and topoisomerase II poison. Cancer cells that develop resistance to bisantrene tend to overexpress P-glycoprotein. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance. The data suggest that bisantrene is an excellent substrate for P-glycoprotein.
| Molecular Weight | 398.46 |
| Formula | C22H22N8 |
| CAS Number | 78186-34-2 |
| Solubility (25°C) | deionized water: 8 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Rui Su, et al. Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
[5] M Artman, et al. Depression of cardiac function by bisantrene
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