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Bik BH3

Cat. No. M41326
Bik BH3 Structure
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Biological Activity

Bik BH3 is a biological active peptide.

Chemical Information
Molecular Weight 2109.4
Formula C86H145N23O32S3
CAS Number 505070-08-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shirin Hafezi et al. Cancers (Basel). Targeting BCL-2 in Cancer: Advances, Challenges, and Perspectives

[2] L Bodet et al. Br J Cancer. BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma

[3] G Chinnadurai et al. Oncogene. BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes

[4] R Rashmi et al. Oncogene. BH3-only protein BIK induces caspase-independent cell death with autophagic features in Bcl-2 null cells

[5] Jaigi P Mathai et al. J Biol Chem. BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death

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Keywords: Bik BH3 supplier, Bcl-2, inhibitors, activators

 
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