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BI-671800

Cat. No. M20981

All AbMole products are for research use only, cannot be used for human consumption.

BI-671800 Structure
Synonym:

AP-761, Cmpd A

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Quality Control & Documentation
Biological Activity

BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS.

Chemical Information
Molecular Weight 501.5
Formula C25H26F3N5O3
CAS Number 1093108-50-9
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] David Miller, et al. Allergy Asthma Proc. A randomized study of BI 671800, a CRTH2 antagonist, as add-on therapy in poorly controlled asthma

[2] Ibrahim Sulaiman, et al. Pulm Pharmacol Ther. Molecularly targeted therapies for asthma: Current development, challenges and potential clinical translation

[3] Ian P Hall, et al. Pulm Pharmacol Ther. Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment

[4] Norbert Krug, et al. J Allergy Clin Immunol. Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis

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Keywords: BI-671800, AP-761, Cmpd A supplier, Prostaglandin Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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