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Bestatin hydrochloride

Cat. No. M14298
Bestatin hydrochloride Structure

Ubenimex hydrochloride

Size Price Availability Quantity
10mg USD 87  USD87 In stock
50mg USD 215  USD215 In stock
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Quality Control & Documentation
Biological Activity

Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

Chemical Information
Molecular Weight 344.83
CAS Number 65391-42-6
Solubility (25°C) DMSO 150 mg/mL
Water 90 mg/mL
Storage 2-8°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Huina Wu, et al. A new method to evaluate the enzyme-suppressing activity of a leucine aminopeptidase 3 inhibitor

[2] Huijie Liu, et al. New Method for Detecting the Suppressing Effect of Enzyme Activity by Aminopeptidase N Inhibitor

[3] Xiaokui Huo, et al. Enhancement effect of P-gp inhibitors on the intestinal absorption and antiproliferative activity of bestatin

[4] Mohana Krishnamoorthy, et al. Exploration of Sitagliptin as a potential inhibitor for the M1 Alanine aminopeptidase enzyme in Plasmodium falciparum using computational docking

[5] Iwona Kudyba, et al. Asymmetric nitroaldol reaction. Synthesis of taxotere side chain and (-)-bestatin using (1R)-8-phenylmenthyl glyoxylate

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Keywords: Bestatin hydrochloride, Ubenimex hydrochloride supplier, Aminopeptidase, inhibitors, activators

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