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Cat. No. M10560
TNP-470 Structure

AGM-1470; NSC 642492

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5mg USD 350  USD350 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

TNP-470 (AGM-1470; NSC 642492) is a synthetic analog of fumagillin (or Fumagillol) and a methionine aminopeptidase-2 inhibitor. TNP-470 inhibits cell proliferation, migration and invasion of human cholangiocarcinoma cells in vitro. TNP-470 Suppresses the Tumorigenicity of HT1080 Fibrosarcoma Tumor Through the Inhibition of VEGF Secretion From the Tumor Cells. TNP-470 decreases the migrated cells of KKU-M213 to 26% and of KKU-M214 to 11% (P<0.01). Similarly, TNP-470 also significantly affects cell invasion, the number of invaded cells is reduced to 25% in KKU-M213 (P<0.01) and to 15% in KKU-M214 (P<0.01). 

In vivo, TNP-470 treatment attenuates (P<0.05) liver lipid accumulation compare to high fat fed (HFF) mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 401.88
Formula C19H28ClNO6
CAS Number 129298-91-5
Purity >99%
Solubility DMSO ≥ 85 mg/mL
Storage -20°C, sealed

[1] Duong Thanh Nguyen, et al. IEEE Trans Nanobioscience. TNP-470 Reduces Glioblastoma Angiogenesis in Three Dimensional GelMA Microwell Platform

[2] Sonexai Kidoikhammouan, et al. Asian Pac J Cancer Prev. TNP-470, a methionine aminopeptidase-2 inhibitor, inhibits cell proliferation, migration and invasion of human cholangiocarcinoma cells in vitro

[3] Heather M White, et al. Obesity (Silver Spring). The angiogenic inhibitor TNP-470 decreases caloric intake and weight gain in high-fat fed mice

[4] Yasuko Naganuma, et al. Cancer Sci. Metronomic doxifluridine chemotherapy combined with the anti-angiogenic agent TNP-470 inhibits the growth of human uterine carcinosarcoma xenografts

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Keywords: TNP-470, AGM-1470; NSC 642492 supplier, inhibitors

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