Free shipping on all orders over $ 500

Benzenesulfonamide

Cat. No. M20427
Benzenesulfonamide Structure
Synonym:

Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide

Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Benzenesulfonamide ia an inhibitor of carbonic anhydrases.

Chemical Information
Molecular Weight 157.19
Formula C6H7NO2S
CAS Number 98-10-2
Solubility (25°C) DMSO 31 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bo Zhou, et al. J Asian Nat Prod Res. Synthesis and insecticidal activities of 4-(propargyloxy) benzenesulfonamide derivatives

[2] Rongfei Qin, et al. Eur J Med Chem. Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis

[3] Rajiv Kumar, et al. Arch Pharm (Weinheim). Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors

[4] Seyit Ali Gngr, et al. J Biomol Struct Dyn. N-substituted benzenesulfonamide compounds: DNA binding properties and molecular docking studies

[5] Yoon Hyeun Oum, et al. Bioorg Med Chem. A benzenesulfonamide derivative as a novel PET radioligand for CXCR4

Related Carbonic Anhydrase Products
Acetazolamide sodium

Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX.Acetazolamide reduces the production of intraocular aqueous humor and may be used in glaucoma-related studies.

WES-1

WES-1 is an inhibitor of carbonic anhydrase IX (Ki: 55.9 μM).

CA inhibitor 2

CA inhibitor 2 is a carbonic anhydrase inhibitor (IC50: 0.033 μM).

hCA XII-IN-6

hCA XII-IN-6 is a potent hCA XII inhibitor with a Ki value of 84.2 nM.

Carbonic anhydrase inhibitor 15

Carbonic anhydrase inhibitor 15 is a carbonic anhydrase inhibitor (Ki: 8.5 nM for hCA II).

  Catalog
Abmole Inhibitor Catalog




Keywords: Benzenesulfonamide, Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide supplier, Carbonic Anhydrase, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.