Benzenesulfonamide ia an inhibitor of carbonic anhydrases.
Molecular Weight | 157.19 |
Formula | C6H7NO2S |
CAS Number | 98-10-2 |
Solubility (25°C) | DMSO 31 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related Carbonic Anhydrase Products |
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Acetazolamide sodium
Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX.Acetazolamide reduces the production of intraocular aqueous humor and may be used in glaucoma-related studies. |
WES-1
WES-1 is an inhibitor of carbonic anhydrase IX (Ki: 55.9 μM). |
CA inhibitor 2
CA inhibitor 2 is a carbonic anhydrase inhibitor (IC50: 0.033 μM). |
hCA XII-IN-6
hCA XII-IN-6 is a potent hCA XII inhibitor with a Ki value of 84.2 nM. |
Carbonic anhydrase inhibitor 15
Carbonic anhydrase inhibitor 15 is a carbonic anhydrase inhibitor (Ki: 8.5 nM for hCA II). |
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