BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that enhances T cell initiation of suboptimal tumor antigens by inhibiting DGKζ. In addition, BAY 2965501 induces pERK activation.BAY 2965501 can be used in cancer research.
| Molecular Weight | 414.45 |
| Formula | C20H19FN4O3S |
| CAS Number | 2732902-08-6 |
| Form | Solid |
| Storage | Powder -20°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related DGK Products |
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| BAY-2862789
BAY-2862789 is a DGKA inhibitor that can be used in studies related to respiratory diseases and tumors. |
| GS-9911
GS-9911 is a DGKA inhibitor that can be used in studies related to solid tumors. |
| (S)-BAY 2965501
(S)-BAY 2965501 is the left-handed isomer of BAY 2965501 (HY-153343).BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKz) inhibitor and induces pERK activation. BAY 2965501 is a potent and selective inhibitor of diacylglycerol kinase zeta (DGKz) and induces pERK activation. |
| Momordicine I
Momordicine I, a triterpenoid compound extracted from momordica charantia L. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ. |
| DGKζ-IN-1
DGKζ-IN-1 is an inhibitor of DGKζ. |
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