(S)-BAY 2965501 is the left-handed isomer of BAY 2965501 (HY-153343).BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKz) inhibitor and induces pERK activation. BAY 2965501 is a potent and selective inhibitor of diacylglycerol kinase zeta (DGKz) and induces pERK activation.
Molecular Weight | 414.45 |
Formula | C20H19FN4O3S |
CAS Number | 2732902-09-7 |
Form | Solid |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related DGK Products |
---|
BAY-2862789
BAY-2862789 is a DGKA inhibitor that can be used in studies related to respiratory diseases and tumors. |
GS-9911
GS-9911 is a DGKA inhibitor that can be used in studies related to solid tumors. |
Momordicine I
Momordicine I, a triterpenoid compound extracted from momordica charantia L. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ. |
DGKζ-IN-1
DGKζ-IN-1 is an inhibitor of DGKζ. |
AMB639752
AMB639752 is a potent DGKα inhibitor. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.