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AZ8838 

Cat. No. M29230

All AbMole products are for research use only, cannot be used for human consumption.

AZ8838  Structure

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Quality Control & Documentation
Biological Activity

AZ8838 is a potent, competitive, allosteric, orally active non-peptide small molecule antagonist of PAR2 with a pKi of 6.4 for hPAR2.

Chemical Information
Molecular Weight 234.27
Formula C13H15FN2O
CAS Number 2100285-41-2
Form Solid
Solubility (25°C) DMSO 200 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kathryn A McIntosh, et al. Biochem Soc Trans. The development of proteinase-activated receptor-2 modulators and the challenges involved

[2] Aarti Kawatkar, et al. ACS Chem Biol. CETSA beyond Soluble Targets: a Broad Application to Multipass Transmembrane Proteins

[3] Robert K Y Cheng, et al. Nature. Structural insight into allosteric modulation of protease-activated receptor 2

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  Catalog
Abmole Inhibitor Catalog




Keywords: AZ8838  supplier, PAR, inhibitors, activators

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