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Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation. Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F can be used in antibody-drug conjugates (ADC).
| Molecular Weight | 745.99 |
| Formula | C40H67N5O8 |
| CAS Number | 163768-50-1 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage | 4°C, dry, sealed |
| Related Microtubule Products |
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| Fosbretabulin disodium
Fosbretabulin disodium (Combretastatin A-4 phosphate) is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. |
| Noscapine hydrochloride
Noscapine, a phthalideisoquinoline alkaloid constituting 1–10% of the alkaloid content of opium, has been used as a cough suppressant. |
| Triclabendazole
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| CYT997
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