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Cat. No. M11421
AUNP-12 TFA Structure


Size Price Availability
5mg USD 330  USD330 Custom Synthesis
10mg USD 550  USD550 Custom Synthesis
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Quality Control
  • Current batch:
  • Purity >96%
  • COA
  • MSDS
Biological Activity

Aunp-12 (NP-12) TFA is a peptide antagonist of the PD-1 signaling pathway, which has an equivalent antagonistic effect on PD-L1 and PD-L2 in terms of inhibiting lymphocyte proliferation and effector function. Aunp-12 TFA has immune-activating effect and good anti-tumor activity, which has the potential to better study immune-related adverse events (irAEs).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 3375.57
Formula C5H17TFIN2O2S2Si
CAS Number 1353563-85-5(free base)
Purity >96%
Solubility N/A
Storage at -20°C
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Abmole Inhibitor Catalog

Keywords: AUNP-12 TFA, NP-12 TFA supplier, PD-1/PD-L1, inhibitors

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