Atinumab (6A3-IgG4) is an antibody. Teropavimab can be used for the research of spinal cord injury (SCI).
| CAS Number | 1226761-65-4 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Q Richier, et al. Rev Med Interne. [COVID-19: Still a place for tocilizumab?]
[3] Lesley J Scott. Drugs. Tocilizumab: A Review in Rheumatoid Arthritis
[4] John H Stone, et al. N Engl J Med. Trial of Tocilizumab in Giant-Cell Arteritis
[5] Anthony Sebba. Am J Health Syst Pharm. Tocilizumab: the first interleukin-6-receptor inhibitor
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