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Asciminib (ABL001) hydrochloride is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC50 of 0.25 nM. Asciminib (ABL001) hydrochloride binds to the myristoyl pocket of ABL1 and induces the formation of an inactive kinase conformation.
| Molecular Weight | 486.30 |
| Formula | C20H19Cl2F2N5O3 |
| CAS Number | 2119669-71-3 |
| Solubility (25°C) | DMSO 95 mg/mL |
| Storage | 4°C, dry, sealed |
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