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AS1708727 

Cat. No. M28048

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AS1708727  Structure

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Quality Control & Documentation
Biological Activity

AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively.

Chemical Information
Molecular Weight 443.37
Formula C24H24Cl2N2O2
CAS Number 1253226-93-5
Form Solid
Solubility (25°C) DMSO 41.67 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] David Flores, et al. FEBS Open Bio. The FOXO1 inhibitor AS1842856 triggers apoptosis in glioblastoma multiforme and basal-like breast cancer cells

[2] Hirotsugu Tanaka, et al. Eur J Pharmacol. Effects of the novel Foxo1 inhibitor AS1708727 on plasma glucose and triglyceride levels in diabetic db/db mice

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  Catalog
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Keywords: AS1708727  supplier, Autophagy, inhibitors, activators

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