All AbMole products are for research use only, cannot be used for human consumption.
APTO-253 (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through induction of the Krüppel-like factor 4 (KLF4) tumor suppressor. APTO-253 has antiarthritic activity. APTO-253 (LOR-253) is an inducer of KLF4. APTO-253 (5 μM) induces KLF4 expression, and enhances apoptosis induced by NSC 119875 in both SKOV3 and OVCAR3 cells. APTO-253 (5 μM) also leads to G1 phase arrest and reduces S and G2/M phase cells in SKOV3 and OVCAR3 cells.
APTO-253 (LOR-253; 15 mg/kg; IV; twice per day for 2 consecutive days per week for 14 days) has antiarthritic activity in a CIA model.
| Molecular Weight | 367.38 |
| CAS Number | 916151-99-0 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Michael J Duffy, et al. Cancer Treat Rev. MYC as a target for cancer treatment
| Related c-Myc Products |
|---|
| MDEG-541
MDEG-541 is a potent MYC-MAX degrader. |
| c-Myc inhibitor 11
c-Myc inhibitor 11 is a c-MYC inhibitor (pEC50: 6.4). |
| c-Myc inhibitor 12
c-Myc inhibitor 12 is an inhibitor of c-Myc with a pEC50 of 6.4. |
| m-Se3
m-Se3 is a potent and selective c-MYC transcription inhibitor that can inhibit tumor growth and has anti-cancer activity. |
| c-Myc inhibitor 10
c-Myc inhibitor 10, a c-Myc inhibitor, exhibits increased cellular potency, consistent with an increase in permeability with methylation of the morpholine nitrogen. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
