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Antineoplaston A10

Cat. No. M20741
Antineoplaston A10 Structure
Size Price Availability Quantity
5mg USD 125  USD125 In stock
10mg USD 225  USD225 In stock
25mg USD 400  USD400 In stock
50mg USD 700  USD700 In stock
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Quality Control & Documentation
Biological Activity

Antineoplaston A10 is a naturally occurring substance in the human body that that can be potentially used for the treatment of glioma, lymphoma, astrocytoma and breast cancer. The main ingredient active of antineoplaston A10 (Phenylacetylglutamine, PG) inhibits RAS and promotes apoptosis.

Chemical Information
Molecular Weight 246.26
Formula C13H14N2O3
CAS Number 91531-30-5
Solubility (25°C) DMSO 49 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Suqin Duan, et al. Virol Sin. Pathogenic analysis of coxsackievirus A10 in rhesus macaques

[2] PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Antineoplastons (PDQ®): Patient Version

[3] Xian-Jun Qu, et al. Anticancer Res. Induction of apoptosis in human hepatocellular carcinoma cells by synthetic antineoplaston A10

[4] Stanislaw R Burzynski, et al. Drugs R D. Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic brain stem glioma: a preliminary report

[5] H Tsuda, et al. Kurume Med J. Inhibitory effect of antineoplaston A10 and AS2-1 on human hepatocellular carcinoma

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Keywords: Antineoplaston A10 supplier, Ras, inhibitors, activators


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