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Anagyrine

Cat. No. M30160

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Anagyrine Structure
Synonym:

(-)-Anagyrine; Monolupine; Rhombinine

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Quality Control & Documentation
Biological Activity

Anagyrine ((-)-Anagyrine) is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine is a potent and effective desensitizer of nAChR, and Anagyrine can directly, without metabolism, desensitize nAChR.

Chemical Information
Molecular Weight 244.33
Formula C15H20N2O
CAS Number 486-89-5
Form Oil
Storage 4°C, protect from light
References

[1] Benedict T Green, et al. Res Vet Sci. Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle

[2] Kambarali K Turgunov, et al. Acta Crystallogr E Crystallogr Commun. Crystal structure of anagyrine perchlorate

[3] R F Keeler, et al. J Environ Pathol Toxicol. The total alkaloid and anagyrine contents of some bitter and sweet selections of lupin species used as food

[4] R H Finnell, et al. J Pediatr. Anagyrine-induced congenital defects

[5] J A Ortega, et al. J Pediatr. Anagyrine-induced red cell aplasia, vascular anomaly, and skeletal dysplasia

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Keywords: Anagyrine, (-)-Anagyrine; Monolupine; Rhombinine supplier, AChR/AChE, inhibitors, activators

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