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AMY-101

Cat. No. M28401

All AbMole products are for research use only, cannot be used for human consumption.

AMY-101 Structure
Synonym:

Cp40

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Quality Control & Documentation
Biological Activity

AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.

Chemical Information
Molecular Weight 1789.11
Formula C83H117N23O18S2
CAS Number 1427001-89-5
Solubility (25°C) Water
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Panagiotis Skendros, et al. Sci Adv. Complement C3 inhibition in severe COVID-19 using compstatin AMY-101

[2] Gianluigi Ardissino, et al. Pharmaceuticals (Basel). Complement System as a New Target for Hematopoietic Stem Cell Transplantation-Related Thrombotic Microangiopathy

[3] Tetsuhiro Kajikawa, et al. Semin Immunol. C3-targeted host-modulation approaches to oral inflammatory conditions

[4] Hatice Hasturk, et al. J Clin Invest. Phase IIa clinical trial of complement C3 inhibitor AMY-101 in adults with periodontal inflammation

[5] Dimitrios C Mastellos, et al. Clin Immunol. Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy

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Keywords: AMY-101, Cp40 supplier, Complement System, inhibitors, activators

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