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Amuvatinib hydrochloride

Cat. No. M27723

All AbMole products are for research use only, cannot be used for human consumption.

Amuvatinib hydrochloride Structure
Synonym:

MP470 hydrochloride; HPK 56 hydrochloride

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Quality Control & Documentation
Biological Activity

Amuvatinib hydrochloride (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib hydrochloride (MP470 hydrochloride) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair. Antineoplastic activity.

Chemical Information
Formula C23H21N5O3S.xHCl
CAS Number 1055986-67-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Daruka Mahadevan, et al. Oncotarget. Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST)

[2] Wenqing Qi, et al. BMC Cancer. MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer

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  Catalog
Abmole Inhibitor Catalog




Keywords: Amuvatinib hydrochloride, MP470 hydrochloride; HPK 56 hydrochloride supplier, c-Kit, inhibitors, activators

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