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DCC-2618 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of KIT and PDGFR with potential antineoplastic activity. It also inhibits several other kinases, including VEGFR2, TIE2, PDGFR-beta and CSF1R, thereby further inhibiting tumor cell growth.
| Molecular Weight | 489.47 |
| Formula | C26H21F2N5O3 |
| CAS Number | 1225278-16-9 |
| Solubility (25°C) | DMSO 97 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Ripretinib
[5] No authors listed. Cancer Discov. BLU-285, DCC-2618 Show Activity against GIST
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