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Amoscanate

Cat. No. M29743

All AbMole products are for research use only, cannot be used for human consumption.

Amoscanate Structure
Synonym:

CGP4540

Price and Availability

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Quality Control & Documentation
Biological Activity

Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma.

Chemical Information
Molecular Weight 271.29
Formula C13H9N3O2S
CAS Number 26328-53-0
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage 4°C, dry, sealed
References

[1] H Z Miao. Zhonghua Nei Ke Za Zhi. [Amoscanate induced liver injury. I. Clinical observation (author's transl)]

[2] B S Reddy, et al. Antimicrob Agents Chemother. Conversion of amoscanate to a mutagenic metabolite in gnotobiotic mice implanted with Streptococcus equinus

[3] L K Greene, et al. Am J Trop Med Hyg. Amoscanate as a topically applied chemical for prophylaxis against Schistosoma mansoni infections in mice

[4] T A Shapiro, et al. Am J Trop Med Hyg. Clinical evaluation of amoscanate in healthy male volunteers

[5] B E Barton, et al. J Immunopharmacol. The immune response to a schistosomacide, amoscanate. I. Serum antibody responses

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Keywords: Amoscanate, CGP4540 supplier, Parasite, inhibitors, activators

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