Free shipping on all orders over $ 500

AMG 579 

Cat. No. M27983

All AbMole products are for research use only, cannot be used for human consumption.

AMG 579  Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.

Chemical Information
Molecular Weight 441.48
Formula C25H23N5O3
CAS Number 1227067-61-9
Form Solid
Solubility (25°C) DMSO 41.67 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Damian P Hruszkewycz, et al. Chem Sci. Co/NHPI-mediated aerobic oxygenation of benzylic C-H bonds in pharmaceutically relevant molecules

[2] Qiong Wu, et al. Int J Pharm. Humidity induced phase transformation of poloxamer 188 and its effect on physical stability of amorphous solid dispersion of AMG 579, a PDE10A inhibitor

Related PDE Products
MR-L2

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 μM.

MMPX

MMPX is a potent PDE1 inhibitor.

T-0156 

T-0156 is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor.

TPN171 

TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH).

Mesopram

Mesopram (Daxalipram) is an orally active phosphodiesterase (PDE) 4 inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: AMG 579  supplier, PDE, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.