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AMG-1694 

Cat. No. M28249

All AbMole products are for research use only, cannot be used for human consumption.

AMG-1694  Structure

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Biological Activity

AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals.

Chemical Information
Molecular Weight 533.63
Formula C23H30F3N3O4S2
CAS Number 1361217-07-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] David J St Jean Jr, et al. J Med Chem. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles

[2] Kate S Ashton, et al. J Med Chem. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept

[3] David J Lloyd, et al. Nature. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

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  Catalog
Abmole Inhibitor Catalog




Keywords: AMG-1694  supplier, Glucokinase (GK), inhibitors, activators

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