About 1 result found for searched term "1361217-07-3" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28249 | AMG-1694 | Glucokinase (GK) |
| AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals. | ||
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