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GKM-001

Cat. No. M31411

All AbMole products are for research use only, cannot be used for human consumption.

GKM-001 Structure

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Quality Control & Documentation
Biological Activity

GKM-001 is a glucokinase (GK) activator that can be used in studies related to type 2 diabetes.

Chemical Information
Molecular Weight 580
Formula C25H20ClF2N3O5S2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
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MK-0941 free base 

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AMG-1694 

AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals.

  Catalog
Abmole Inhibitor Catalog




Keywords: GKM-001 supplier, Glucokinase (GK), inhibitors, activators

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