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AM404

Cat. No. M11426

All AbMole products are for research use only, cannot be used for human consumption.

AM404  Structure
Synonym:

N-(4-HYDROXYPHENYL)-ARACHIDONYLAMIDE

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Quality Control & Documentation
Biological Activity

AM404 is an endocannabinoid reuptake inhibitor that can block anandamide transport with IC50 values in the low mole range. The isolated rat hepatic artery was constricted by norepinephrine and relaxed by AM404. PEC50 value was 7.4 (corresponding EC50 value was 0.04 µM). It has neuroprotective effects.

Chemical Information
Molecular Weight 395.58
Formula C26H37NO2
CAS Number 183718-77-6
Storage -20°C
References

[1] Soraya Wilke Saliba, et al. Front Cell Neurosci. Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity

[2] Hei-Jen Huang, et al. Psychopharmacology (Berl). Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

[3] Evelien Gerits, et al. Clin Exp Dent Res. Repurposing AM404 for the treatment of oral infections by Porphyromonas gingivalis

[4] Brian J Anderson. Paediatr Anaesth. Paracetamol (Acetaminophen): mechanisms of action

[5] Alfio Bertolini, et al. CNS Drug Rev. Paracetamol: new vistas of an old drug

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  Catalog
Abmole Inhibitor Catalog




Keywords: AM404 , N-(4-HYDROXYPHENYL)-ARACHIDONYLAMIDE supplier, Cannabinoid, inhibitors, activators

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