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α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
| Molecular Weight | 148.11 |
| Formula | C5H8O5 |
| CAS Number | 2889-31-8 |
| Form | Liquid |
| Storage | -20°C |
[1] James A Nathan. Science. Metabolite-driven antitumor immunity
[2] Yi-Ping Wang, et al. J Biol Chem. Metabolite sensing and signaling in cancer
[3] Petr Ježek. Antioxid Redox Signal. 2-Hydroxyglutarate in Cancer Cells
[4] Takeo Fujii, et al. Discov Med. Targeting isocitrate dehydrogenase (IDH) in cancer
[5] Lenny Dang, et al. Nature. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
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