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Alniditan dihydrochloride

Cat. No. M10779
Alniditan dihydrochloride Structure
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Biological Activity

Anidetam dihydrochloride Alniditan (Alnitidan) dihydrochloride is an effective one 5-HT1B and 5-HT1D RECEPTOR AGONISTS, IN HEK 293 CELLS, IN HUMANS 5-HT1B and people 5-HT1D receptors IC50 1.7 nM and 1.3 nM, respectively. Alniditan dihydrochloride has the effect of preventing migraines.

Chemical Information
Molecular Weight 375.33642
Formula C17H28Cl2N4O
CAS Number 155428-00-5
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A Van de Water, et al. Eur J Pharmacol. Selective vasoconstriction by alniditan in the carotid vascular bed of anaesthetized dogs

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