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Alniditan dihydrochloride

Cat. No. M10779
Alniditan dihydrochloride Structure
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Anidetam dihydrochloride Alniditan (Alnitidan) dihydrochloride is an effective one 5-HT1B and 5-HT1D RECEPTOR AGONISTS, IN HEK 293 CELLS, IN HUMANS 5-HT1B and people 5-HT1D receptors IC50 1.7 nM and 1.3 nM, respectively. Alniditan dihydrochloride has the effect of preventing migraines.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 375.33642
Formula C17H28Cl2N4O
CAS Number 155428-00-5
Purity >98%
Solubility N/A
Storage at -20°C
References

[1] A Van de Water, et al. Eur J Pharmacol. Selective vasoconstriction by alniditan in the carotid vascular bed of anaesthetized dogs

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