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Cat. No. M10778
Aldumastat  Structure


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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Aldumastat (GLPG1972; S201086) is a potent, selective, orally active ADAMTS-5 (IC50=19 nM) inhibitor, whose selectivity is ADAMTS-4 (IC50=8 times 156 nM). Aldumastat has antimetabolic activity for osteoarthritis research.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 406.43
Formula C20H24F2N4O3
CAS Number 1957278-93-1
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
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Abmole Inhibitor Catalog

Keywords: Aldumastat , GLPG1972 supplier, inhibitors

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