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Aldoxorubicin

Cat. No. M13746
Aldoxorubicin Structure
Synonym:

INNO-206; DOXO-EMCH

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Aldoxorubicin (INNO-206) is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models.

<span style='color:#ff0000;'><strong>*The compound is unstable in solutions, freshly prepared is recommended</strong></span>


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 750.75
Formula
CAS Number 1361644-26-9
Purity >99%
Solubility DMSO 55 mg/mL
Storage -20°C, sealed
References

[1] Lee D Cranmer. Onco Targets Ther. Spotlight on aldoxorubicin (INNO-206) and its potential in the treatment of soft tissue sarcomas: evidence to date

[2] Florence E Chamberlain, et al. Future Oncol. Aldoxorubicin in soft tissue sarcomas

[3] Mahesh Seetharam, et al. Future Oncol. Aldoxorubicin therapy for the treatment of patients with advanced soft tissue sarcoma

[4] Jun Gong, et al. Drug Des Devel Ther. Aldoxorubicin: a tumor-targeted doxorubicin conjugate for relapsed or refractory soft tissue sarcomas

[5] Esha Sachdev, et al. Expert Opin Investig Drugs. Aldoxorubicin for the treatment of soft tissue sarcoma

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Keywords: Aldoxorubicin, INNO-206; DOXO-EMCH supplier, Topoisomerase, inhibitors

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