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Cat. No. M13746
Aldoxorubicin Structure


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Biological Activity

Aldoxorubicin (INNO-206) is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models.

<span style='color:#ff0000;'><strong>*The compound is unstable in solutions, freshly prepared is recommended</strong></span>

Chemical Information
Molecular Weight 750.75
CAS Number 1361644-26-9
Solubility (25°C) DMSO 55 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Lee D Cranmer. Onco Targets Ther. Spotlight on aldoxorubicin (INNO-206) and its potential in the treatment of soft tissue sarcomas: evidence to date

[2] Florence E Chamberlain, et al. Future Oncol. Aldoxorubicin in soft tissue sarcomas

[3] Mahesh Seetharam, et al. Future Oncol. Aldoxorubicin therapy for the treatment of patients with advanced soft tissue sarcoma

[4] Jun Gong, et al. Drug Des Devel Ther. Aldoxorubicin: a tumor-targeted doxorubicin conjugate for relapsed or refractory soft tissue sarcomas

[5] Esha Sachdev, et al. Expert Opin Investig Drugs. Aldoxorubicin for the treatment of soft tissue sarcoma

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MC-DOXHZN hydrochloride

MC-DOXHZN ((E/Z)-Aldoxorubicin) hydrochloride is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties.

Abmole Inhibitor Catalog

Keywords: Aldoxorubicin, INNO-206; DOXO-EMCH supplier, Topoisomerase, inhibitors, activators

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