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Akt/NF-κB/MAPK-IN-1

Cat. No. M42148
Akt/NF-κB/MAPK-IN-1 Structure
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Biological Activity

Akt/NF-κB/MAPK-IN-1 is a potent and orally active inhibitor against NO (IC50=7.70 μM) with no significant toxicity.

Chemical Information
Molecular Weight 604.86
Formula C38H56N2O4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jiabao Liu et al. Biomed Pharmacother. Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K/Akt/NF-κB and NLRP3/caspase-1/GSDMD signaling

[2] Dan Li et al. Acta Pharmacol Sin. Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways

[3] Yan Sun et al. ACS Chem Neurosci. Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus

[4] EunJin Bang et al. Redox Biol. Protease-activated receptor 2 induces ROS-mediated inflammation through Akt-mediated NF-κB and FoxO6 modulation during skin photoaging

[5] Meiling Yu et al. Biomed Pharmacother. Baicalein increases cisplatin sensitivity of A549 lung adenocarcinoma cells via PI3K/Akt/NF-κB pathway

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Keywords: Akt/NF-κB/MAPK-IN-1 supplier, p38 MAPK, inhibitors, activators

 
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