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AG-555 is an inhibitor of tyrosine kinase , interacts directly with topoisomerase I, thus preventing DNA relaxation. It inhibits EGFR with an IC50 of 0.7 μM.
| Molecular Weight | 322.36 |
| Formula | C19H18N2O3 |
| CAS Number | 133550-34-2 |
| Solubility (25°C) | DMSO 64 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] N Osherov, et al. FEBS Lett. Tyrphostin AG 494 blocks Cdk2 activation
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