Free shipping on all orders over $ 500

Adjudin

Cat. No. M9159
Adjudin Structure
Synonym:

AF-2364

Size Price Availability Quantity
10mM*1mL USD 87  USD87 In stock
5mg USD 80  USD80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Adjudin (also known as AF-2364) is a potent Cl- channel blocker, with a superior mitochondria-inhibitory effect. Adjudin inhibits cell proliferation in a dose dependent manner in SGC-7901 (human gastric adenocarcinoma cell), MDA-MB-231 (human breast adenocarcinoma cell), Smmc-7721 (human hepatoma cell) and MIA Paca-2 (human pancreatic adenocarcinoma cell) cells. The IC50 of Adjudin is determined to be 58.0 µM, 13.8 µM, 72.3 µM and 52.7 µM against SGC-7901, MDA-MB-231, Smmc-7721 and MIA Paca-2 cells, respectively, after treatment for 24 h. Similar results are obtained in other human and mice cancer cell lines. The IC50 of Adjudin in A549 cells and PC3 cells is 63.1 µM and 93.0 µM, respectively. Adjudin-treated mice show significant tumor growth inhibition compared with the control group (P<0.0001 in the human lung carcinoma cells A549 and P=0.006 in the prostate carcinoma cells PC3).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 335.19
Formula C15H12Cl2N4O
CAS Number 252025-52-8
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

[1] Li K, et al. Hum Reprod. Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans.

Related Products
3,3-Dimethyl-1-butanol (liquid)

3,3-Dimethyl-1-butanol (DMB) is an indirect inhibitors of TMAO, which can reduce plasma TMAO levels. 3,3-Dimethyl-1-butanol is a branched alkanol, which can be used as a ligand in the preparation of nickel based single-molecule magnets.

Cadisegliatin (TTP-399)

Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes.

Bepirovirsen

Bepirovirsen is an antisense oligonucleotide targeting all HBV messenger RNAs. Bepirovirsen leads to reductions in HBV-derived RNAs, HBV DNA and viral proteins.

Violacein

Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.

Cytidine-5'-monophospho-N-acetylneuraminic acid

Cytidine-5'-monophospho-N-acetylneuraminic acid is a nucleotide.

  Catalog
Abmole Inhibitor Catalog




Keywords: Adjudin, AF-2364 supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.