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Acotiamide

Cat. No. M20455
Acotiamide Structure
Synonym:

Acofide

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Biological Activity

Acotiamide is a novel acetylcholinesterase inhibitor with fundus-relaxing and gastroprokinetic properties.

Chemical Information
Molecular Weight 450.55
Formula C21H30N4O5S
CAS Number 185106-16-5
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dhan B Shrestha, et al. Cureus. Acotiamide and Functional Dyspepsia: A Systematic Review and Meta-Analysis

[2] Madhusudan Grover, et al. Gut. Gastroparesis: a turning point in understanding and treatment

[3] Masahiro Ueda, et al. Clin Exp Gastroenterol. Profile of acotiamide in the treatment of functional dyspepsia

[4] Jan Tack, et al. Expert Opin Investig Drugs. Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia

[5] H Suzuki, et al. Neurogastroenterol Motil. Acotiamide (Z-338) as a possible candidate for the treatment of functional dyspepsia

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Keywords: Acotiamide, Acofide supplier, AChR/AChE, inhibitors, activators


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