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A-3 Hydrochloride is A potent, cellular permeable, reversible, atP-competitive, non-selective antagonist targeting multiple kinases. A-3 Hydrochloride is an inhibitor of PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM), and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibited PKC and casein kinase I activity with Ki of 47 µM and 80 µM, respectively.
| Molecular Weight | 321.22 |
| Formula | C12H13ClN2O2S · HCl |
| CAS Number | 78957-85-4 |
| Solubility (25°C) | DMSO: 24 mg/mL |
| Storage | 4°C, dry, sealed |
[1] Hassan Kamran, et al. Oral Antiplatelet Therapy After Acute Coronary Syndrome: A Review
[3] Sang Myung Woo. Chemotherapy for Biliary Tract Cancer
[5] H R Kaplan. Bevantolol hydrochloride--preclinical pharmacologic profile
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