Certificate of Analysis

 

Product Name: A3 hydrochloride
Catalog Number: M7590
CAS Number: 78957-85-4

Physical and Chemical Properties
Formula: C12H13ClN2O2S · HCl
Molecular Weight: 321.22
Solubility: DMSO: 24 mg/mL
Storage: 4°C, dry, sealed
Chemical Structure: A3 hydrochloride Structure
Analytical Data
QC Standard: >99%
H-NMR: Consistent with structure
Product Information
Description: A-3 Hydrochloride is A potent, cellular permeable, reversible, atP-competitive, non-selective antagonist targeting multiple kinases. A-3 Hydrochloride is an inhibitor of PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM), and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibited PKC and casein kinase I activity with Ki of 47 µM and 80 µM, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.