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A-836339

Cat. No. M10720
A-836339 Structure
Size Price Availability Quantity
5mg USD 190  USD190 In stock
10mg USD 340  USD340 In stock
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Quality Control & Documentation
Biological Activity

A-836339 is a selective agonist of the cb2 receptor and has little effect on the cb1 receptor.

Chemical Information
Molecular Weight 310.46
Formula C16H26N2O2S
CAS Number 959746-77-1
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] M Salaga, et al. Naunyn Schmiedebergs Arch Pharmacol . Highly selective CB 2 receptor agonist A836339 has gastroprotective effect on experimentally induced gastric ulcers in mice

[2] Rares-Petru Moldovan, et al. J Med Chem . Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor

[3] Gin C Hsieh, et al. Br J Pharmacol . Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats

[4] S McGaraughty, et al. Neuroscience . A CB(2) receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: contributions of spinal and peripheral CB(2) receptors

[5] Geraldine Pottier, et al. J Cereb Blood Flow Metab. PET imaging of cannabinoid type 2 receptors with [ 11 C]A-836339 did not evidence changes following neuroinflammation in rats

[6] Andrew G Horti, et al. Bioorg Med Chem. Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)

[7] S McGaraughty, et al. Neuroscience. A CB(2) receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: contributions of spinal and peripheral CB(2) receptors

[8] Betty B Yao, et al. J Pharmacol Exp Ther. Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and 䲧璷Ỵ璸㧀璶羹瘬癳虸۪ř۪Ā�

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