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Trofinetide

Cat. No. M45379

All AbMole products are for research use only, cannot be used for human consumption.

Trofinetide Structure
Synonym:

NNZ-2566

Size Price Availability Quantity
5mg USD 160  USD160 In stock
10mg USD 255  USD255 In stock
50mg USD 660  USD660 In stock
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Quality Control & Documentation
Biological Activity

Trofinetide, a water-soluble analog of glycine-proline-glutamic acid (GPE), uses the unnatural amino acid 2-methylproline in place of the proline found in the natural compound, and works by enhancing synaptic activity, restoring synaptic structure, inhibiting the effects of inflammatory compounds in the brain, increasing antioxidant responses, reducing injury-induced cell death, and increasing central IGF-1 presence. It has neuroprotective activity and can be used in studies related to Rett syndrome.

Chemical Information
Molecular Weight 315.32
Formula C13H21N3O6
CAS Number 853400-76-7
Form Solid
Solubility (25°C) Water >100 mg/mL
DMSO 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jeffrey L Neul, et al. Nat Med. Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study

[2] Susan J Keam. Drugs. Trofinetide: First Approval

[3] Jeffrey L Neul, et al. Contemp Clin Trials. Design and outcome measures of LAVENDER, a phase 3 study of trofinetide for Rett syndrome

[4] Daniel G Glaze, et al. Neurology. Double-blind, randomized, placebo-controlled study of trofinetide in pediatric Rett syndrome

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Keywords: Trofinetide, NNZ-2566 supplier, Peptides, inhibitors, activators

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