Free shipping on all orders over $ 500

Trofinetide

Cat. No. M45379

All AbMole products are for research use only, cannot be used for human consumption.

Trofinetide Structure
Synonym:

NNZ-2566

Size Price Availability Quantity
1mg USD 60  USD60 In stock
5mg USD 160  USD160 In stock
10mg USD 255  USD255 In stock
50mg USD 660  USD660 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Trofinetide, a water-soluble analog of glycine-proline-glutamic acid (GPE), uses the unnatural amino acid 2-methylproline in place of the proline found in the natural compound, and works by enhancing synaptic activity, restoring synaptic structure, inhibiting the effects of inflammatory compounds in the brain, increasing antioxidant responses, reducing injury-induced cell death, and increasing central IGF-1 presence. It has neuroprotective activity and can be used in studies related to Rett syndrome.

Chemical Information
Molecular Weight 315.32
Formula C13H21N3O6
CAS Number 853400-76-7
Form Solid
Solubility (25°C) Water >100 mg/mL
DMSO 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jeffrey L Neul, et al. Nat Med. Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study

[2] Susan J Keam. Drugs. Trofinetide: First Approval

[3] Jeffrey L Neul, et al. Contemp Clin Trials. Design and outcome measures of LAVENDER, a phase 3 study of trofinetide for Rett syndrome

[4] Daniel G Glaze, et al. Neurology. Double-blind, randomized, placebo-controlled study of trofinetide in pediatric Rett syndrome

Related Peptides Products
Elcatonin

Elcatonin is a synthetic analog of eel calcitonin that increases bone density and inhibits bone resorption.

Pegmolesatide

Pegmolesatide is a synthetic peptide-based erythropoietic agent that may be used in studies related to anemia in chronic kidney disease.

Hemopressin (human, mouse)

Hemopressin is a natriuretic peptide derived from the α1 chain of hemoglobin, originally isolated from rat brain homogenates. Hemopressin is also an orally potent, selective inverse agonist at the CB1 cannabinoid receptor.Hemopressin has anti-injury sensory effects in models of inflammatory pain.

Trypsin Inhibitor (from Soybean)

Trypsin inhibitor is an alkaline polypeptide consisting of 58 amino acid residues with a pear shape throughout the molecule and a lysine activity center. It can compete with the activity center of many proteases for a lysyl group and inhibit their activities.

(D-His2,D-Trp6)-LHRH

(D-His2,D-Trp6)-LHRH is a peptide that can be discovered by peptide screening. Peptide screening is a research tool that assembles active peptides primarily by immunoassay. It can be used for protein interactions, functional analysis, antigenic epitope screening, and the development and study of active molecules.

  Catalog
Abmole Inhibitor Catalog




Keywords: Trofinetide, NNZ-2566 supplier, Peptides, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.