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GNF-5 is a cell-permeable GNF-2 N-hydroxyethyl carboxamide analog.It exhibits in vivo efficacy in suppressing the proliferation of Bcr-abl-expressing Ba/F3 in murine xenograft models of leukemia.GNF-5 shows potent antiproliferative activity with EC50 of 430 nM and 580 nM against wt-Bcr-Abl and E255K mutant Bcr-Abl transformed cells, respectively. GNF-5 is ineffective toward the myristate-binding site mutant E505K and the ATP-binding site 'gatekeeper' mutant T315I.
| Molecular Weight | 418.37 |
| Formula | C20H17F3N4O3 |
| CAS Number | 778277-15-9 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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