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6RK73

Cat. No. M13624

All AbMole products are for research use only, cannot be used for human consumption.

6RK73 Structure

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Quality Control & Documentation
Biological Activity

6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer.

Chemical Information
Molecular Weight 307.37
CAS Number 1895050-66-4
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ning Liu, et al. Clin Transl Med. Both SUMOylation and ubiquitination of TFE3 fusion protein regulated by androgen receptor are the potential target in the therapy of Xp11.2 translocation renal cell carcinoma

[2] Sijia Liu, et al. Clin Cancer Res. Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

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  Catalog
Abmole Inhibitor Catalog




Keywords: 6RK73 supplier, Deubiquitinase, inhibitors, activators

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