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6-Hydroxyluteolin 7-glucoside

Cat. No. M18142
6-Hydroxyluteolin 7-glucoside Structure
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5mg USD 530  USD530 In stock
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Biological Activity

6-Hydroxyluteolin 7-glucoside

Chemical Information
Molecular Weight 464.38
Formula C21H20O12
CAS Number 54300-65-1
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] C A. Williams, et al. Biochem Syst Ecol. The role of lipophilic and polar flavonoids in the classification of temperate members of the Anthemideae

[2] C A Williams, et al. Phytochemistry. The flavonoids of Tanacetum parthenium and T. vulgare and their anti-inflammatory properties

[3] T Yokozawa, et al. Exp Toxicol Pathol. Protective effects of some flavonoids on the renal cellular membrane

[4] E Wjcik. Acta Pol Pharm. [Occurrence of 6-hydroxyluteolin 7-glucoside in the herb of Veronica officinalis L]

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