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5-Hydroxy-8-methoxypsoralen

Cat. No. M18191
5-Hydroxy-8-methoxypsoralen Structure
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5mg USD 700  USD700 In stock
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Biological Activity

5-Hydroxy-8-methoxypsoralen

Chemical Information
Molecular Weight 232.19
Formula C12H8O5
CAS Number 7471-73-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gai-Gai Deng, et al. Zhongguo Zhong Yao Za Zhi. [Chemical constituents from lipophilic parts in roots of Angelica dahurica cv.Yubaizhi]

[2] Ai-Hong Zhao, et al. Phytomedicine. Simultaneous determination and pharmacokinetics of sixteen Angelicae dahurica coumarins in vivo by LC-ESI-MS/MS following oral delivery in rats

[3] Tanya Kruse, et al. Chem Biol. In planta biocatalysis screen of P450s identifies 8-methoxypsoralen as a substrate for the CYP82C subfamily, yielding original chemical structures

[4] D C Mays, et al. J Pharmacol Exp Ther. Disposition of 8-methoxypsoralen in the rat: methodology for measurement, dose-dependent pharmacokinetics, tissue distribution and identification of metabolites

[5] D C Mays, et al. Drug Metab Dispos. Disposition of 8-methoxypsoralen in the rat. Induction of metabolism in vivo and in vitro and identification of urinary metabolites by thermospray mass spectrometry

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