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5-Bromoindole

Cat. No. M20489
5-Bromoindole Structure
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Biological Activity

5-bromoindole is an important pharmaceutical chemical intermediate and a potential inhibitor of glycogen synthase kinase 3 (GSK-3).

Chemical Information
Molecular Weight 196.04
Formula C8H6BrN
CAS Number 10075-50-0
Solubility (25°C) DMSO 39 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Krystal M Butler-Fernndez, et al. Molecules. Synthesis, Anti-Cancer and Anti-Migratory Evaluation of 3,6-Dibromocarbazole and 5-Bromoindole Derivatives

[2] Malose J Mphahlele, et al. Pharmaceuticals (Basel). Synthesis, Evaluation of Cytotoxicity and Molecular Docking Studies of the 7-Acetamido Substituted 2-Aryl-5-bromo-3-trifluoroacetylindoles as Potential Inhibitors of Tubulin Polymerization

[3] J Tupper, et al. Cancer Gene Ther. In vivo characterization of horseradish peroxidase with indole-3-acetic acid and 5-bromoindole-3-acetic acid for gene therapy of cancer

[4] Oscar R Surez-Castillo, et al. J Nat Prod. Synthesis of bromoindole alkaloids from Laurencia brongniartii

[5] Deniz Tasdemir, et al. Z Naturforsch C J Biosci. Cytotoxic bromoindole derivatives and terpenes from the Philippine marine sponge Smenospongia sp

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Keywords: 5-Bromoindole supplier, GSK-3, inhibitors, activators
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