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4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis.
| Molecular Weight | 130.14 |
| Formula | C6H10O3 |
| CAS Number | 816-66-0 |
| Form | Liquid (density 1.055 g/mL) |
| Solubility (25°C) | DMSO 90 mg/mL Water 90 mg/mL |
| Storage | 2-8°C, protect from light |
| Related Metabolite/Endogenous Metabolite Products |
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| Casein (from bovine milk)
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| Palmitic acid-13C16
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| Methionine sulfoximine
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| L-Glutamine-15N2
L-Glutamine-15N2 is the 15N-labeled L-Glutamine. L-Glutamine is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells. |
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